SHVM

19th Annual Scientific Sessions:

Metabolic Modulation of Diabetes and Cardiovascular Diseases: From Mechanisms to Novel Treatment

SHVM

19th Annual Scientific Sessions:

Metabolic Modulation of Diabetes and Cardiovascular Diseases: From Mechanisms to Novel Treatment

Seoul, South Korea 16-19 October 2022

Seoul, South Korea
16-19 October 2022

Programme

  • 08:00-09:30

    SHVM Board meeting   [4F of Convention Center_Oak Room]

    09:00-18:00

    Registration   [from 9:00 to 13:00 B1 of Grand Walkerhill_Foyer, from 13:00 to 18:00 B1 of Grand Walkerhill_GRAND 4 entrance]

    09:30-12:00

    Pre-Meeting Trainee Workshops
    “Cutting-Edge Technologies for Metabolism Research”   [B1 of Grand Walkerhill_GRAND 4]

    Chairs: Chan Bae Park (Suwon, South Korea) and Miranda Nabben (Maastricht, The Netherlands)

    09:30-09:55

    Jihwan Park (GIST, South Korea)
    Single cell profiling reveals that metabolic reprogramming drives cell differentiation and protects from kidney fibrosis

    09:55-10:20

    Yong Sook Kim (Chonnam National University, South Korea)
    Understanding and applications of spacial transcriptomics in the heart

    10:20-10:45

    Pilhan Kim (KAIST, South Korea)
    Intravital two-photon imaging of cardiac lipid droplets in a live animal model

    10:45-11:10

    Young-Kook Kim (Chonnam National University, South Korea)
    Exploring the role of non-coding RNA in cardiovascular diseases

    11:10-11:35

    Jeong-Min Kim (Seoul National University, South Korea)
    Cerebral atherosclerosis research with PET

    11:35-12:00

    Dae Ho Lee (Gachon University, South Korea)
    From bench to clinic: in vivo measurements of total lipids – beyond MR spectroscopy

    12:00-13:00

    Box Lunch   [B1 of Grand Walkerhill_GRAND 4]

    13:00-13:30

    Welcome Address and Preliminary Remarks   [B1 of Grand Walkerhill_GRAND 1]

    Jaetaek Kim, In-Kyu Lee, E. Dale Abel, Terje Larsen

    13:30-14:10

    Keynote Lecture   [B1 of Grand Walkerhill_GRAND 1]

    Chair: E. Dale Abel (Los Angeles, CA, USA)

    In-Kyu Lee (Kyungpook National University, South Korea)
    Role of PDK4 in mitochondrial quality control and dynamics

    Session 1 – Novel Metabolic Signaling Pathways in the Vasculature   [B1 of Grand Walkerhill_GRAND 1]

    Chairs: Hyun Kook (Hwasun, South Korea) and Jason Dyck (Edmonton, Canada)

    14:10-14:35

    Zoltan Arany (University of Pennsylvania, USA)
    Metabolic signaling in the vasculature

    14:35-15:00

    Kyu-Sang Park (Yonsei University Wonju College of Medicine, South Korea)
    Mitochondrial phosphate transporters in vascular calcification

    15:00-15:30

    Coffee break   [B1 of Grand Walkerhill_GRAND 2+3/Foyer]

    15:30-15:55

    Sung Joon Kim (Seoul National University, South Korea)
    Myosin light chain diphosphorylation and impaired relaxation of pulmonary arteries in monocrotaline-induced pulmonary arterial hypertensive rats

    15:55-16:10

    Short talk: Alice Marino (Université Catholique de Louvain, Belgium)
    Sodium myo-inositol cotransporter 1 affects cardiac hypertrophy in pressure-overloaded mouse hearts

    16:10-16:25

    Short talk: Barbora Opletalová (Inst Physiology CAS, Czech Republic)
    HIF-1α: an essential element for cardioprotection and proper mitochondrial function during adaptation to chronic hypoxia

    16:30-18:00

    Poster Session 1   [B1 of Grand Walkerhill_GRAND 2+3/Foyer]

    18:00

    Welcome Reception   [Aston House]

  • 5:45

    Departure for Achasan Mountain trail   [1F of Grand Walkerhill_Lobby]
    (optional; see the Information page)

    7:20-8:20

    Breakfast Symposium [sponsored by LG Chem]   [B1 of Grand Walkerhill_GRAND 4]

    Chair: You cheol Hwang (Seoul, South Korea)

    Jun Hwa Hong (Daejeon Eulji Hospital, South Korea)
    The combination of DPP-4 inhibitor plus SGLT2 inhibitor as attractive treatment option: from rationale to clinical aspects

    Session 2 – Myocardial Substrate Signaling in Heart Failure   [B1 of Grand Walkerhill_GRAND 1]

    Chairs: Soon Jun Hong (Seoul, South Korea) and Veronique Lacombe (Stillwater, OK, USA)

    8:30-8:55

    Ippei Shimizu (Juntendo University, Japan)
    Pathogenic roles of age-related metabolites in the synchronization of aging

    8:55-9:20

    Rong Tian (University of Washington, USA)
    Immunometabolism in the pathogenesis of heart failure

    9:20-9:45

    Julie McMullen (Baker Heart Institute, Australia)
    Lipids species predict atrial fibrillation in patients with diabetes

    9:45-10:10

    Rebecca Ritchie (Monash University, Australia)
    Regulation of energy metabolism in diabetic cardiomyopathy

    10:10-10:35

    Dunja Aksentijevic (Queen Mary University of London, UK)
    With a grain of salt: Sodium elevation and metabolic remodelling in heart failure

    10:35-10:50

    Coffee break   [B1 of Grand Walkerhill_GRAND 2+3/Foyer]

    10:50-11:05

    Short talk: Maria Victoria Faith Garcia (Inje University, South Korea)
    Novel creatine kinase tyrosine residue phosphorylation protect the heart during ischemic cardiomyopathy

    11:05-11:20

    Short talk: Laurent Bultot (UCLouvain, Belgium)
    Enhanced protein acetylation initiates fatty acid-mediated inhibition of cardiac glucose transport

    11:20-11:35

    Short talk: Francesco Schianchi (Maastricht University, The Netherlands)
    Protein palmitoylation: the missing mediator in the development of cardiac lipid-induced insulin resistance?

    11:35-11:50

    Short talk: Florin Despa (The University of Kentucky, USA)
    In vivo downregulation of pancreatic amylin in diabetic mice improves systemic and central glucose homeostasis

    11:50-12:50

    Luncheon Symposium   [B1 of Grand Walkerhill_GRAND 1]

    Chair: Cheol-Young Park (Seoul, South Korea)

    Jung Hwan Park (College of Medicine, Hanyang University, South Korea)
    How to find the optimal combination therapy for patients with Type 2 diabetes

    13:30

    Departure for tour of Gyeongbokgung Palace and dinner   [1F of Grand Walkerhill_Lobby]
    (see the Information page)

  • 7:00-8:00

    Breakfast Symposium [sponsored by Boehringer Ingelheim, Lilly]   [B1 of Grand Walkerhill_GRAND 4]

    Chair: Byung Jin Kim (Seoul, South Korea)

    Eun-Jung Rhee (Sungkyunkwan University College of Medicine, Kangbuk Samsung Hospital, South Korea)
    Cardiorenal protection in T2D, is it time to re-think the 1st line therapy?

    7:00-8:00

    Breakfast Symposium [sponsored by Novartis]   [B1 of Grand Walkerhill_GRAND 5]

    Chair: Dae Ho Lee (Seoul, South Korea)

    Yongho Lee (Yonsei University, South Korea)
    Paradigm changes after VERIFY study

    8:00-8:40

    Keynote Lecture   [B1 of Grand Walkerhill_GRAND 1]

    Chair: Jaetaek Kim (Seoul, South Korea)

    E. Dale Abel (UCLA, USA)
    The next century of insulin signaling in the cardiovascular system

    8:40-9:00

    Coffee break   [B1 of Grand Walkerhill_GRAND 2+3/Foyer]

    Session 3 – Cardiac Ketone Signaling   [B1 of Grand Walkerhill_GRAND 1]

    Chairs: Young Mi Park (Seoul, South Korea) and Dunja Aksentijevic (London, United Kingdom)

    9:00-9:25

    Peter A. Crawford (University of Minnesota, USA)
    Cardiac ketone signaling - Regulation of systemic ketone metabolism

    9:25-9:50

    Jason Dyck (University of Alberta, Canada)
    The role of ketones in regulating cardiac inflammation in heart failure

    9:50-10:15

    Yongho Lee (Yonsei University, South Korea)
    Unravelling the cardio-protective mechanism of SGLT2 inhibitors: inflammasome, ketones and others

    10:15-10:40

    Dan Kelly (University of Pennsylvania, USA)
    Probing the beneficial role of ketones for the failing heart

    10:40-10:55

    Short talk: Kaya Persad (University of Alberta, Canada)
    Ketones promote maturation of proliferating H9c2 cardiomyocytes

    10:55-11:10

    Short talk: Anna Kovilakath (Virginia Commonwealth University, USA)
    Inhibition of the novel sphingolipid enzyme SPTLC3 is protective in an animal model of ischemic heart failure

    11:30-12:30

    Luncheon Symposium [sponsored by Viatris]   [B1 of Grand Walkerhill_GRAND 1]

    Chair: In-Kyung Jeong (Seoul, South Korea)

    Nam Hoon Kim (Korea University Anam Hospital, South Korea)
    Lower for longer: LDL-C target focus on cardiovascular disease

    12:30-14:45

    Poster Session 2   [B1 of Grand Walkerhill_GRAND 2+3/Foyer]

    Session 4 – Metabolic Insights in HFpEF   [B1 of Grand Walkerhill_GRAND 1]

    Chairs: Wang Soo Lee (Seoul, South Korea) and Rong Tian (Seattle, WA, USA)

    14:45-15:10

    John Ussher (University of Alberta, Canada)
    Glucose oxidation as a therapeutic target for alleviating diastolic dysfunction in diabetic cardiomyopathy

    15:10-15:35

    Dan Tong (University of Texas Southwestern Medical Center, USA)
    Impaired AMPK signaling in HFpEF-associated atrial myopathy

    15:35-16:00

    Jong-Chan Youn (The Catholic University of Korea, South Korea)
    Senescent T cell driven inflammation in heart failure

    16:00-16:25

    John W. Elrod (Temple University, USA)
    Metabolic pathways underlying cardiac fibrosis

    16:25-16:40

    Short talk: Qiuyu Sun (University of Alberta, Canada)
    Cardiac glucose oxidation is suppressed in heart failure with preserved ejection fraction

    16:40-16:55

    Short talk: Mathias Mericskay (Paris-Saclay University, France)
    Nicotinamide riboside supplementation administrated after experimental myocardial infarction in rats results in a more favourable left ventricular remodeling and improved survival

    Session 5 – The "William C. Stanley" Early Investigator Awards   [B1 of Grand Walkerhill_GRAND 1]

    Chairs: Florin Despa (Kensington, KY, USA) and Estelle Heyne (Jena, Germany)

    16:55-17:10

    Nikole Byrne (Medical University of Graz, Austria)
    Overexpression of Sirtuin 4 accelerates heart failure development upon increasing mitochondrial oxidative stress and myocardial fibrosis

    17:10-17:25

    Kaitlyn Dennis (University of Oxford, UK)
    Selective palmitoylation of CD36 is associated with metabolic dysfunction in the type 2 diabetic heart

    17:25-17:40

    Kyle Fulghum (University of Louisville, KY, USA)
    Coordinated metabolic responses facilitate exercise-induced cardiac growth

    17:40-17:55

    Christina Reumiller (King’s College London, UK)
    The role of c-Myc in regulating cardiac glucose intermediary metabolism

    18:30

    Gala Dinner   [1F of Convention Center_Walker Hall]
    Beautiful Harmony Concert
    (full details here )

  • 8:00-9:00

    Breakfast Symposium [sponsored by Sanofi]   [B1 of Grand Walkerhill_GRAND 4]

    Chair: Woo Je Lee (Seoul, South Korea)

    Chang Hee Jung (University of Ulsan College of Medicine, Asan Medical Center, South Korea)
    Attribute of ideal insulin

    9:00-9:40

    "William C. Stanley" Award Lecture   [B1 of Grand Walkerhill_GRAND 1]

    Chair: Terje Larsen (Tromsø, Norway)

    Jan Glatz (Maastricht University, The Netherlands)
    Re-balancing energy substrate metabolism to mend the failing heart

    9:40-10:00

    Coffee break   [B1 of Grand Walkerhill_GRAND 2+3/Foyer]

    Session 6 – Novel Mechanisms of Cardiac Disease   [B1 of Grand Walkerhill_GRAND 1]

    Chairs: Sung Joon Kim (Seoul, South Korea) and Julie McMullen (Melbourne, Australia)

    10:00-10:25

    Sun-Hee Woo (Chungnam National University, South Korea)
    Distinct remodeling on local calcium signaling in right and left atrial myocytes under increased afterload

    10:25-10:50

    Heiko Bugger (Medical University of Graz, Austria)
    Molecular characterization of the human diabetic heart

    10:50-11:15

    Motohiro Nishida (Kyushu University, Japan)
    Regulation of cardiac robustness by reactive sulfide species

    11:15-11:30

    Short talk: Sylvain Fraineau (Normandy University, France)
    EZH2 epigenetic enzyme inhibition prevents the perturbations of lipid metabolism and improves cardiac dysfunction in a myocardial infarction mouse model

    11:30-11:45

    Short talk: Jordan Chan (University of Alberta, Canada)
    Growth differentiation factor 15 alleviates diastolic dysfunction in experimental diabetic cardiomyopathy

    11:45-12:00

    SHVM 2022 Meeting Summary   [B1 of Grand Walkerhill_GRAND 1]

    Organisers and SHVM President

    12:00-12:10

    Invitation to SHVM 2023   [B1 of Grand Walkerhill_GRAND 1]

    12:10-13:00

    Closing Remarks and Box Lunch

  • Presenters should attend their poster boards on the indicated day during the following presentation hours:

    • Poster Session 1: Odd numbered posters from 16:30 to 18:00 on Sunday, 16 October
    • Poster Session 2: Even numbered posters from 12:30 to 14:45 on Tuesday, 18 October

    When preparing your poster please remember that the poster boards have maximum surface area of 100 x 250 cm (width x height). We recommend using a standard format: A0 (841 x 1189 mm; width x height).

    Correct format... poster should be PORTRAIT    poster should NOT be LANDSCAPE Wrong format...

    Pins will be available at the poster boards. Please use a poster material that is light enough to be secured with pins.

    The poster should contain a header including the abstract title, all authors and their affiliations and your poster number (please check the list below). Your poster number, which is also your board number, should appear in the upper left corner of the header in Arial Black Font – 100 pt size.

    The poster sessions will be held from 16:30 to 18:00 on Sunday and 12:30 to 14:45 on Tuesday at the 1st basement Grand Hall.

    You should attend your poster at least for the indicated hours, according to the odd/even poster numbering.

    You should mount your poster on your specified board from 12:00 pm on Sunday to 12:00 pm on Wednesday. Posters should be removed at the end of the meeting. Posters left on the boards after 14:00 on Wednesday will be discarded.

    P.1 Amira Abd Jamil (Kuala Lumpur, Malaysia)
    Cardiometabolic effect of thermally oxidised palm oil in dietary induced rodent model of type II diabetes

    P.2 Jiyoung Bae (Stillwater, OK, USA)
    The role of carnitine palmitoyltransferase (CPT) 1 in neonatal heart regeneration

    P.3 Sun Sik Bae (Yangsan, South Korea)
    Redox status in the pathological responses of vascular smooth muscle cells

    P.4 Nam Bui (Busan, South Korea)
    Majonoside-R2 postconditioning protects cardiomyocytes against hypoxia/reoxygenation injury by attenuating the expression of HIF1a and activating RISK pathway

    P.5 Laurent Bultot (Brussels, Belgium)
    Enhanced protein acetylation initiates fatty acid-mediated inhibition of cardiac glucose transport

    P.6 Nikole Byrne (Graz, Austria)
    Overexpression of Sirtuin 4 accelerates heart failure development upon increasing mitochondrial oxidative stress and myocardial fibrosis

    P.7 Jordan Chan (Edmonton, Canada)
    Growth differentiation factor 15 alleviates diastolic dysfunction in experimental diabetic cardiomyopathy

    P.8 Seung Hak Choi (Busan, South Korea)
    Resistance exercise improves heart and mitochondrial function in a diabetic rat heart model

    P.9 Valentin Clapatiuc (Montreal, Canada)
    The use of alkylglycerol in cardiomyoblastic cells prevents the disturbances of lipid metabolism induced by loss of ether lipids synthesis

    P.10 Julien Cumps (Brussels, Belgium)
    Plasmatic myo-inositol elevation in heart failure with preserved ejection: a potential metabolic actor in the disease pathophysiology and clinical outcome

    P.11 Chloé David (Montréal, Canada)
    A B vitamins-enriched synthetic diet improves survival only in mouse female with heart failure through the amelioration of cardiac function and lipid dishomeostasis

    P.12 Kaitlyn Dennis (Oxford, United Kingdom)
    Selective palmitoylation of CD36 is associated with metabolic dysfunction in the type 2 diabetic heart

    P.14 Thomas Dupas (Nantes, France)
    The O-GlcNAcylation is not only regulated by nutrient availability

    P.15 Jessa Flores (Busan, South Korea)
    Protective effect of HS‑1793 against oxidative stress in C2C12 cells via regulation of mitochondrial function

    P.16 Sylvain Fraineau (Rouen, France)
    EZH2 epigenetic enzyme inhibition prevents the perturbations of lipid metabolism and improves cardiac dysfunction in a myocardial infarction mouse model

    P.17 Kyle Fulghum (Louisville, KY, USA)
    Coordinated metabolic responses facilitate exercise-induced cardiac growth

    P.18 Maria Victoria Faith Garcia (Busan, South Korea)
    Novel creatine kinase tyrosine residue phosphorylation protect the heart during ischemic cardiomyopathy

    P.19 Chae-Myeong Ha (Birmingham, AL, USA)
    Differential impact of specific pyruvate dehydrogenase kinase (PDK) isozymes on protein acetylation and metabolism in the heart

    P.20 Estelle Heyne (Jena, Germany)
    Skeletal muscle but not cardiac mitochondrial function correlates with differences in life expectancy of rats with inherited high and low exercise capacity

    P.21 Nguyen Hoai (Busan, South Korea)
    Empagliflozin prevents diabetic cardiomyopathy by attenuating cardiac lipotoxicity in type 2 diabetic db/db mice

    P.22 Martijn Hoes (Maastricht, The Netherlands)
    Designing a platform to study genetic variants of uncertain significance for cardiovascular disease

    P.23 Jae-Han Jeon (Daegu, South Korea)
    The critical role of pyruvate dehydrogenase kinase (PDK)-lactate-hypoxia-inducible factor-1α (HIF1α) axis in adpiogenesis and obesity

    P.24 Jae Woo Jung (Philadelphia, PA, USA)
    One-carbon metabolism defect in failing heart

    P.25 Hyeon-Ji Kang (Daegu, South Korea)
    The protective role of pyruvate dehydrogenase kinase 4 inhibition on doxorubicin induced cardiomyopathy

    P.26 Ezra Ketema (Edmonton, Canada)
    Alterations in protein lysine acetylation do not contribute to the high rates of fatty acid oxidation seen in the post-ischemic heart

    P.27 Amy Kim (Busan, South Korea)
    FABP3 and IGFBP as potential biomarkers for early onset of diabetic cardiomyopathy

    P.28 Hyoung Kyu Kim (Busan, South Korea)
    BH4 modulates cardiac mitochondrial metabolism in a diabetic cardiomyopathy model

    P.29 Yong Sook Kim (Gwangju, South Korea)
    IKKε deficiency reduces p38 activity of macrophages to increases cardiac injury

    P.30 Véronique Lacombe (Stillwater, OK, USA)
    Prolonged hyperinsulinemia increases the production of inflammatory cytokines and acute phase proteins in lamellae but not in equine cardiac muscle

    P.31 Yong Sook Kim (Gwangju, South Korea)
    ANGPTL4 reduces atherosclerosis and promotes fibrous cap stability by targeting KLF4 in vascular smooth muscle cells

    P.32 Jaetaek Kim (Seoul, South Korea)
    α-tubulin deacetylation impairs angiogenesis and induces endothelial-to-mesenchymal transition

    P.33 Jeong-Min Kim (Seoul, South Korea)
    Elevated miR-93-5p from thrombus is associated with recurrent vascular event after cerebral infarction

    P.34 Terje Larsen (Tromsø, Norway)
    Hydrolysed wax ester from Calanus oil alleviates palmitate-induced lipotoxic stress

    P.35 Hoyul Lee (Daegu, South Korea)
    Deletion of pyruvate dehydrogenase kinase 4 in CD4+ T cells attenuates experimental colitis

    P.36 Ji-Min Lee (Daegu, South Korea)
    Inhibition of PDK ameliorates atherosclerosis through the hepatic FGF21-AMPK activation pathway

    P.37 Yongho Lee (Seoul, South Korea)
    Statin use is associated with newly developed low calf circumference in older patients with type 2 diabetes

    P.38 Alice Marino (Brussels, Belgium)
    Sodium myo-inositol cotransporter 1 affects cardiac hypertrophy in pressure-overloaded mouse hearts

    P.39 Jubert Marquez (Busan, South Korea)
    Novel marine compound Neopetroside A inhibits GSK-3β to confer cardioprotection against murine myocardial ischemia/reperfusion injury

    P.40 Matthew Martens (Edmonton, Canada)
    The role of reactive oxygen species modulator 1 (ROMO1) in the heart

    P.41 Bellina Mushala (Pittsburgh, PA, USA)
    The adropin-GPR19 signaling axis in diabetic cardiomyopathy

    P.42 Miranda Nabben (Maastricht, The Netherlands)
    Ketone body exposure of cardiomyocytes impairs insulin sensitivity and contractile function through vacuolar-type H+-ATPase disassembly. Rescue by specific amino acid supplementation

    P.43 Ha Nguyen (Wonju, South Korea)
    Activation of sarco/endoplasmic reticulum Ca2+ ATPase increases mitochondrial biogenesis and protects pancreatic β-cells from lipotoxicity

    P.44 Ha Nguyen (Wonju, South Korea)
    Peri-lysosomal calcium overload by palmitate in pancreatic β-cells

    P.45 Thien Nguyen Huu (Busan, South Korea)
    Tetrahydrobiopterin improves mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling

    P.46 Chang Joo Oh (Daegu, South Korea)
    Loss of pyruvate dehydrogenase kinase 4 inhibits cisplatin-induced acute renal failure

    P.47 Barbora Opletalová (Prague, Czech Republic)
    HIF-1α: an essential element for cardioprotection and proper mitochondrial function during adaptation to chronic hypoxia

    P.48 Linda Peterson (Saint Louis, MO, USA)
    Metabolic therapy aand imaging of pancreatic cancer wiht sodium glucose cotransporter 2 inhibitors (SGLT2i): A phase 1b clinical trial.

    P.49 Kaya Persad (Edmonton, Canada)
    Ketones promote maturation of proliferating H9c2 cardiomyocytes

    P.50 Linda Peterson (Saint Louis, MO, USA)
    Excellent performance of a prediction model for all-cause mortality that incorporates plasma C24:0/C16:0 ceramide

    P.51 Chan Bae Park (Suwon, South Korea)
    Novel D-lactate metabolism in heart

    P.52 Muhammad Fazril Razif (Kuala Lumpur, Malaysia)
    Anti-oxidative Effects of Functional Food, Lignosus rhinocerus Sclerotia (TM02® cultivar) using a Type 2 Diabetes Mellitus Rodent Model

    P.53 Gabriel Reimann (Jena, Germany)
    Complex III defect by UQCRH-KO increases preischemic glycolysis, impairs insulin response but preserves recovery of contractile function after ischemia of the isolated working mouse heart

    P.54 Christina Reumiller (London, United Kingdom)
    The role of c-Myc in regulating cardiac glucose intermediary metabolism

    P.55 Matthew Rochowski (Stillwater, OK, USA)
    SARS-CoV-2 infection induces alteration of cardiac glucose metabolism in a feline model

    P.56 Francesco Schianchi (Maastricht, The Netherlands)
    Protein palmitoylation: the missing mediator in the development of cardiac lipid-induced insulin resistance?

    P.57 Pauke Schots (Tromsø, Norway)
    Fatty acids isolated from calanus oil prevent palmitate-induced cell death

    P.58 Michael Schwarzer (Jena, Germany)
    Aging is not related to increased mitochondrial ROS production in a rat model of genetically determined high or low exercise capacity

    P.59 Dae Yun Seo (Busan, South Korea)
    The effect of exercise on cisplatin and atorvastatin-induced myopathy in rats

    P.60 Alena Spagnolo (Jena, Germany)
    Reduced complex I threshold in aging rats with low intrinsic exercise capacity is related to reduced lifespan

    P.61 Qiuyu Sun (Edmonton, Canada)
    Cardiac glucose oxidation is suppressed in heart failure with preserved ejection fraction

    P.62 Ji Hee Sung (Busan, South Korea)
    Mitochondrial energy metabolic transcriptome profiles during cardiac differentiation from mouse and human pluripotent stem cells

    P.63 Marten Szibor (Jena, Germany)
    Alternative oxidase impairs long-term adaptive remodeling in the post-ischemic mouse heart

    P.64 Themis Thoudam (Daegu, South Korea)
    Non-canonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status

    P.65 Job Verdonschot (Maastricht, The Netherlands)
    Metabolic changes in titin cardiomyopathy

    P.66 David Weissman (Würzburg, Germany)
    Interplay between the lysosomal and cellular metabolism in myofibroblast activation in Fabry cardiomyopathy

    P.67 Yang Xiang (Davis, CA, USA)
    Cardiac beta2 adrenergic receptor promotes glucose uptake and metabolism in heart

    P.68 Anton Xu (Würzburg, Germany)
    Role of creatine kinase in an energy starved muscle in HCM